Letrozole

Description: When Letrozole (Femara) is used to treat infertility, it is used for the treatment of ovulatory dysfunction. The medication is supplied as 2.5mg tablets only and is administered orally.

How It Works: Letrozole works by temporarily decreasing the amount of estrogen in the body, which then stimulates the pituitary gland to release higher amounts of follicle stimulating hormone (FSH). This sends the brain a false message implying that there is an estrogen deficiency in the blood stream. In response, the pituitary gland releases more FSH and luteinizing hormone (LH), which stimulates the follicles (the fluid filled cysts which contain the eggs) to develop in the ovaries. The increased levels of FSH in turn have a beneficial effect on the ovary to allow a follicle, or sometimes more than one follicle to develop.

Potential Side Effects: Side effects might include hot flashes, visual spots in front of the eyes, headaches and mood changes. Multiple births occur in 5-10% of pregnancies. Excessive enlargement of the ovaries, called ovarian hyperstimulation syndrome (OHSS) may also occur. The risk of OHSS should be discussed with your physician prior to treatment. Symptoms of OHSS include excessive fluid retention and severe abdominal discomfort, nausea, vomiting and weight gain.

 

If you experience an allergic reaction: difficulty breathing; closing of the throat, swelling of the lips, tongue, or face; or hives; seek emergency medical treatment immediately.

PLEASE NOTE: If these or any other side effects occur, contact your physician.

Storage: Store Letrozole at room temperature.